Abstract
In adults, GH replacement therapy will often be maintained for decades. Owing to the long duration of GH replacement in many adults, it is essential to establish the long-term safety aspects of the treatment. In this review, studies that have investigated the safety profile of long-term GH replacement will be reviewed with an emphasis on studies based on data from the Pfizer International Metabolic Database (KIMS). These studies show that long-term GH replacement in adults is safe and that long-term GH replacement may even improve cardiovascular mortality and morbidity in GH-deficient adults.
MeSH terms
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Adult
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Cardiovascular Diseases / epidemiology*
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Cardiovascular Diseases / mortality
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Cardiovascular Diseases / prevention & control
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Databases, Factual
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Diabetes Mellitus, Type 2 / chemically induced
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Diabetes Mellitus, Type 2 / epidemiology*
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Diabetes Mellitus, Type 2 / metabolism
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Human Growth Hormone / administration & dosage
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Human Growth Hormone / adverse effects*
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Human Growth Hormone / deficiency*
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Humans
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Hypothalamic Neoplasms / epidemiology
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Insulin / metabolism
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International Cooperation
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Neoplasm Recurrence, Local / epidemiology
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Neoplasms / chemically induced
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Neoplasms / epidemiology*
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Pituitary Neoplasms / epidemiology
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Risk Assessment
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Risk Factors
Substances
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Insulin
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Human Growth Hormone