Abstract
A series of 4H-pyrazolo[1,5-a]pyrimidin-7-one derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase. A number of these compounds exhibited potent activity in enzymatic assay. The synthesis and structure-activity relationship are also described.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Hepacivirus / enzymology*
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Models, Molecular
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Protein Binding
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Pyrimidines / chemistry
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Pyrimidines / pharmacology*
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RNA-Dependent RNA Polymerase / antagonists & inhibitors
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RNA-Dependent RNA Polymerase / metabolism
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Structure-Activity Relationship
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Viral Nonstructural Proteins / antagonists & inhibitors*
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Viral Nonstructural Proteins / metabolism*
Substances
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Antiviral Agents
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Pyrazoles
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Pyrimidines
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Viral Nonstructural Proteins
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NS-5 protein, hepatitis C virus
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RNA-Dependent RNA Polymerase