Oxygenated lignans from the fruits of Schisandra arisanensis

J Nat Prod. 2009 Sep;72(9):1663-8. doi: 10.1021/np9003678.

Abstract

An acetone extract of the fruits of the Taiwanese medicinal plant Schisandra arisanensis has yielded 11 new oxygenated lignans. Four of these, named arisantetralones A-D (1-4), possess the aryltetralone skeleton, while the other seven, named arisanschinins F-L (5-11), are polyoxygenated C(18)-dibenzocyclooctadiene lignans. Structures were determined on the basis of spectroscopic analyses, especially 2D-NMR techniques. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Immunomodulatory activity of the isolated lignans was tested and evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Fruit / chemistry
  • Humans
  • Immunologic Factors / blood
  • Immunologic Factors / chemistry
  • Immunologic Factors / isolation & purification*
  • Immunologic Factors / pharmacology
  • Lignans / blood
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / pharmacology
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oxygen / chemistry
  • Plants, Medicinal / chemistry*
  • Schisandra / chemistry*
  • Taiwan

Substances

  • Immunologic Factors
  • Lignans
  • Oxygen