Abstract
The dichloromethane extract of the air-dried leaves of Sphaeranthus africanus afforded four new carvotanacetone derivatives (1, 2, 3A, and 3B). Their structures were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1- 3 exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Trichophyton mentagrophytes and Aspergillus niger.
Georg Thieme Verlag KG Stuttgart . New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Aspergillus niger / drug effects
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Asteraceae / chemistry*
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Candida albicans / drug effects
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Ethylene Oxide / analogs & derivatives*
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Ethylene Oxide / chemistry*
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Fungi / drug effects*
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Microbial Sensitivity Tests
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Leaves
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Pseudomonas aeruginosa / drug effects*
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Staphylococcus aureus / drug effects*
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Trichophyton / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Plant Extracts
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Ethylene Oxide