Abstract
Four compounds were isolated from scrap cultivation beds of the mushroom, Hericium erinaceum. Compounds 1-4 were identified as methyl 4-hydroxy-3-(3-methylbutanoyl) benzoate, 2-chloro-1,3-dimethoxy-5-methylbenzene, methyl 4-chloro-3,5-dimethoxybenzoate, and 4-chloro-3,5-dimethoxybenzaldehyde by an interpretation of the NMR and MS data, respectively. This is the first reported isolation of 1 from a natural source. All the compounds showed protective activity against endoplasmic reticulum stress-dependent cell death.
MeSH terms
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Basidiomycota / chemistry*
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Basidiomycota / growth & development*
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Benzaldehydes / chemistry
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Benzaldehydes / isolation & purification
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Benzaldehydes / pharmacology
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Benzene / chemistry
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Benzene / isolation & purification
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Benzene / pharmacology
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Benzoates / chemistry
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Benzoates / isolation & purification
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Benzoates / pharmacology
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Cell Death / drug effects
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Cell Line, Tumor
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Endoplasmic Reticulum / drug effects*
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Endoplasmic Reticulum / pathology
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Stress, Physiological / drug effects*
Substances
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Benzaldehydes
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Benzoates
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Benzene
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benzaldehyde