Possible role of human leukocyte antigen-G molecules in human oocyte/embryo secretome

Roberta Rizzo; Marina Stignani; Loredana Melchiorri; Olavio R Baricordi

doi:10.1016/j.humimm.2009.07.020

Possible role of human leukocyte antigen-G molecules in human oocyte/embryo secretome

Hum Immunol. 2009 Dec;70(12):970-5. doi: 10.1016/j.humimm.2009.07.020. Epub 2009 Aug 3.

Authors

Roberta Rizzo¹, Marina Stignani, Loredana Melchiorri, Olavio R Baricordi

Affiliation

¹ Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy. rbr@unife.it

PMID: 19654031
DOI: 10.1016/j.humimm.2009.07.020

Abstract

Human leucocyte antigen-G (HLA-G) is a nonclassical HLA class I molecule observed for the first time in human cytotrophoblast. Several investigations have demonstrated the presence of soluble HLA-G in oocyte/embryo secretome. A focus on the possible role of HLA-G in oocyte/embryo context will be developed in this review. In addition, the possible use of HLA-G in assisted reproductive technology will be treated.

Publication types

Review

MeSH terms

Embryo, Mammalian / immunology
Embryo, Mammalian / metabolism*
Female
Follicular Fluid / immunology
Follicular Fluid / metabolism*
HLA Antigens / immunology
HLA Antigens / metabolism*
HLA-G Antigens
Histocompatibility Antigens Class I / immunology
Histocompatibility Antigens Class I / metabolism*
Humans
Maternal-Fetal Relations
Oocytes / immunology
Oocytes / metabolism*
Receptors, Immunologic / immunology
Receptors, Immunologic / metabolism*
Receptors, KIR2DL5

Substances

HLA Antigens
HLA-G Antigens
Histocompatibility Antigens Class I
Receptors, Immunologic
Receptors, KIR2DL5