No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample

Psychiatry Res. 2009 Sep 30;169(2):164-6. doi: 10.1016/j.psychres.2008.12.004. Epub 2009 Jul 31.

Abstract

Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes are being studied for association with lithium prophylaxis in a sample of 155 Sardinian unrelated probands affected by bipolar disorder (BP). No significant association was shown between the polymorphisms of the genes studied and response to lithium treatment.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antimanic Agents / therapeutic use*
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / genetics*
  • Dopamine Plasma Membrane Transport Proteins / genetics*
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Italy / epidemiology
  • Italy / ethnology
  • Lithium Compounds / therapeutic use*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Receptor, Serotonin, 5-HT2A / genetics*
  • Receptors, Dopamine / genetics*
  • Receptors, Dopamine D1 / genetics
  • Receptors, Dopamine D2 / genetics
  • Receptors, Dopamine D3 / genetics
  • Serotonin Plasma Membrane Transport Proteins / genetics*
  • Statistics as Topic

Substances

  • Antimanic Agents
  • Dopamine Plasma Membrane Transport Proteins
  • Lithium Compounds
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins