Increasing concerns on public health safety have led researchers to develop efficient methods to characterize veterinary drugs and pesticides residues simultaneously in animal products. This investigation presents a simple and rapid method to determine five types of fluoroquinolones (FQs), organophosphorus (OP) and N-methyl carbamates (NMCs) in porcine tissue simultaneously with the use of matrix solid-phase dispersion (MSPD), high performance liquid chromatography (HPLC) and diode array detection (DAD). The results show a recovery ratio of 60.1-107.7% with satisfactory relative standard deviations. The limits of detection (LOD) in porcine tissue are between 9 and 22microg/kg. The applicability of the method to the multiresidue analysis in porcine tissue is reported in this contribution.