Direct palladium-catalyzed arylations of aryl bromides with 2/9-substituted pyrimido[5,4-b]indolizines

Min Jiang; Ting Li; Linghua Meng; Chunhao Yang; Yuyuan Xie; Jian Ding

doi:10.1021/cc800162k

Direct palladium-catalyzed arylations of aryl bromides with 2/9-substituted pyrimido[5,4-b]indolizines

J Comb Chem. 2009 Sep-Oct;11(5):806-8. doi: 10.1021/cc800162k.

Authors

Min Jiang¹, Ting Li, Linghua Meng, Chunhao Yang, Yuyuan Xie, Jian Ding

Affiliation

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 PR China.

PMID: 19645499
DOI: 10.1021/cc800162k

Abstract

C-5 arylated 2/9-substituted pyrimido[5,4-b]indolizines were synthesized via palladium-catalyzed direct arylation. A variety of substituents on both pyrimido[5,4-b]indolizines and aryl/heteroaryl bromides are tolerated, providing rapid access to substituted pyrimido[5,4-b]indolizines in good to excellent yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bromides / chemistry*
Catalysis
Indolizines / chemistry*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Palladium / chemistry*

Substances

Bromides
Indolizines
Palladium