Superoxide production by broncho-alveolar cells is diminished in parainfluenza-3 virus treated guinea pigs

G Folkerts; B van Esch; M Janssen; F P Nijkamp

doi:10.1007/978-3-0348-7379-6_18

Superoxide production by broncho-alveolar cells is diminished in parainfluenza-3 virus treated guinea pigs

Agents Actions Suppl. 1990:31:139-42. doi: 10.1007/978-3-0348-7379-6_18.

Authors

G Folkerts¹, B van Esch, M Janssen, F P Nijkamp

Affiliation

¹ Dept. of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.

PMID: 1964360
DOI: 10.1007/978-3-0348-7379-6_18

Abstract

Guinea pig airways isolated 4, 8 and 16 days (but not 2 days) after intra-tracheal inoculation with parainfluenza-3 virus In Vivo respond hyperreactive to contractile stimuli. In the present study it is shown that the virus-induced airway hyperresponsiveness is associated with a decreased Superoxide production by broncho-alveolar cells after additional stimulation with parainfluenza-3 virus.

MeSH terms

Animals
Bronchoalveolar Lavage Fluid / metabolism*
Bronchoalveolar Lavage Fluid / pathology
Guinea Pigs
Male
Parainfluenza Virus 3, Human / physiology*
Paramyxoviridae Infections / metabolism*
Paramyxoviridae Infections / pathology
Superoxides / metabolism*
Time Factors

Substances

Superoxides