Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells

Saad Shabaan; Lalla A Ba; Muhammad Abbas; Torsten Burkholz; Annika Denkert; André Gohr; Ludger A Wessjohann; Florenz Sasse; Wolfgang Weber; Claus Jacob

doi:10.1039/b823149d

Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells

Chem Commun (Camb). 2009 Aug 21:(31):4702-4. doi: 10.1039/b823149d. Epub 2009 Jun 22.

Authors

Saad Shabaan¹, Lalla A Ba, Muhammad Abbas, Torsten Burkholz, Annika Denkert, André Gohr, Ludger A Wessjohann, Florenz Sasse, Wolfgang Weber, Claus Jacob

Affiliation

¹ Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany.

PMID: 19641815
DOI: 10.1039/b823149d

Abstract

Multicomponent Passerini and Ugi reactions enable the fast and efficient synthesis of redox-active multifunctional selenium and tellurium compounds, of which some show considerable cytotoxicity against specific cancer cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Cell Line, Tumor
Humans
Inhibitory Concentration 50
Mice
Molecular Structure
Organometallic Compounds / chemical synthesis*
Organometallic Compounds / chemistry
Oxidation-Reduction
Selenium / chemistry*
Tellurium / chemistry*

Substances

Antineoplastic Agents
Organometallic Compounds
Selenium
Tellurium