Bactericidal activity of vancomycin, daptomycin, ampicillin and aminoglycosides against vancomycin-resistant Enterococcus faecium

E Bingen; N Lambert-Zechovsky; R Leclercq; C Doit; P Mariani-Kurkdjian

doi:10.1093/jac/26.5.619

Bactericidal activity of vancomycin, daptomycin, ampicillin and aminoglycosides against vancomycin-resistant Enterococcus faecium

J Antimicrob Chemother. 1990 Nov;26(5):619-26. doi: 10.1093/jac/26.5.619.

Authors

E Bingen¹, N Lambert-Zechovsky, R Leclercq, C Doit, P Mariani-Kurkdjian

Affiliation

¹ Laboratoire de Microbiologie, Hôpital Robert Debré Université Paris VII, France.

PMID: 1964156
DOI: 10.1093/jac/26.5.619

Abstract

Daptomycin, vancomycin, ampicillin and aminoglycosides, alone or in combination, were tested for their bactericidal activity against 15 isolates of vancomycin-resistant Enterococcus faecium from immunocompromised children. The kill-kinetic studies at clinically achievable concentrations demonstrated that daptomycin alone or in combination with ampicillin had the greatest bactericidal activity.

Publication types

Comparative Study

MeSH terms

Aminoglycosides
Ampicillin / pharmacology
Anti-Bacterial Agents / pharmacology*
Conjugation, Genetic
Daptomycin
Drug Resistance, Microbial
Drug Synergism
Kinetics
Microbial Sensitivity Tests
Peptides / pharmacology
Streptococcal Infections / microbiology
Streptococcus / drug effects*
Vancomycin / pharmacology*

Substances

Aminoglycosides
Anti-Bacterial Agents
Peptides
Vancomycin
Ampicillin
Daptomycin