Abstract
Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccine-elicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Animals
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Gene Products, gag / administration & dosage
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Gene Products, gag / immunology
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Gene Products, pol / administration & dosage
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Gene Products, pol / immunology
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Humans
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Lymphocyte Activation
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Macaca mulatta
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Male
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RNA, Viral / analysis
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RNA, Viral / blood
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Reverse Transcriptase Polymerase Chain Reaction
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SAIDS Vaccines / administration & dosage
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SAIDS Vaccines / immunology*
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Semen / virology*
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / prevention & control
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Simian Acquired Immunodeficiency Syndrome / transmission
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / immunology
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Simian Immunodeficiency Virus / isolation & purification*
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Simian Immunodeficiency Virus / pathogenicity
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T-Lymphocytes / immunology*
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Vaccination
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Viral Load
Substances
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Gene Products, gag
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Gene Products, pol
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RNA, Viral
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SAIDS Vaccines