Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba=N,N-dimethylbenzylamine, tu=thiourea)

Eur J Med Chem. 2009 Nov;44(11):4611-5. doi: 10.1016/j.ejmech.2009.06.032. Epub 2009 Jul 4.

Abstract

The reactions between [Pd(C(2),N-dmba)(micro-X)](2) (dmba=N,N-dimethylbenzylamine; X=Cl, Br) and thiourea (tu) in the 1:2 molar ratio at room temperature resulted in the mononuclear compounds [Pd(C(2),N-dmba)(Cl)(tu)] (1) and [Pd(C(2),N-dmba)(Br)(tu)] (2), which were characterized by elemental analyses and infrared (IR), (1)H- and (13)C{(1)H} NMR spectroscopies. The crystal and molecular structures of 2 were determined by single-crystal X-ray diffraction. In vitro cytotoxicity assays of the compounds 1, 2, tu, dmba and cisplatin were carried out using two murine tumor cell lines, namely mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07). The compounds 1, 2, tu and dmba were also tested against Mycobacterium tuberculosis and their MIC values were determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / chemistry*
  • Antibiotics, Antineoplastic / pharmacology*
  • Antibiotics, Antitubercular / chemistry*
  • Antibiotics, Antitubercular / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Infrared Rays
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Mycobacterium tuberculosis / drug effects
  • Palladium / chemistry*
  • Palladium / pharmacology*
  • Thiourea / chemistry
  • Thiourea / pharmacology

Substances

  • Antibiotics, Antineoplastic
  • Antibiotics, Antitubercular
  • Palladium
  • Thiourea