A new dilactone from the seeds of Gaultheria yunnanensis

Jun Li; Fu Li; Yuan-Yuan Lu; Xiao-Jian Su; Cui-Ping Huang; Xue-Wen Lu

doi:10.1016/j.fitote.2009.07.003

A new dilactone from the seeds of Gaultheria yunnanensis

Fitoterapia. 2010 Jan;81(1):35-7. doi: 10.1016/j.fitote.2009.07.003. Epub 2009 Jul 21.

Authors

Jun Li¹, Fu Li, Yuan-Yuan Lu, Xiao-Jian Su, Cui-Ping Huang, Xue-Wen Lu

Affiliation

¹ School of Environmental Science & Resources, Guangxi Normal University, Guilin 541004, China. lijun9593@mailbox.gxnu.edu.cn

PMID: 19628028
DOI: 10.1016/j.fitote.2009.07.003

Abstract

Gaultheriadiolide (1), a new compound, together with the known dauosterol (2), ginkgetin (3), myricetin (4), 6-ethyl-5-hydroxy-2,7-dimethoxy-1,4-naphthoquinone (5), ursolic acid (6), methyl salicylate 2-O-beta-D-xylosyl(1-->6)beta-D-glucopyranoside (7), and methyl salicylate 2-O-beta-D-glucopyranoside (8) were isolated from Gaultheria yunnanensis. The structure was elucidated on the basic of spectral analysis, especially 1D and 2D NMR. Primary bioassays showed that compound 1 had medium cytotoxic activity against HEp-2 and HepG2 Cells, with IC(50) of 23.337 microM and 29.4497 microM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification*
Cell Line, Tumor
Drug Evaluation, Preclinical
Drugs, Chinese Herbal / chemistry
Gaultheria / chemistry*
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / isolation & purification*
Humans
Lactones / chemistry
Lactones / isolation & purification*
Molecular Structure
Seeds / chemistry

Substances

Antineoplastic Agents, Phytogenic
Drugs, Chinese Herbal
Heterocyclic Compounds, 4 or More Rings
Lactones
gaultheriadiolide