Abstract
Ovarian tumors have a low incidence in childhood, accounting for 1% of malignancies within the ages of 0-17 years. Small cell carcinoma of the ovary is a rare histology and historically has a poor prognosis. We report a case of an 11-year-old female diagnosed with small cell carcinoma of the ovary and hypercalcemia (SCCOHT). There was a strong family history of the disease, a reduction in the age of onset in the proband, and the absence of BRCA mutations. This case suggests the phenomenon of genetic anticipation in an ovarian cancer.
(c) 2009 Wiley-Liss, Inc.
MeSH terms
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Abdominal Pain / etiology
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Adult
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Age of Onset
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Anticipation, Genetic*
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bleomycin / administration & dosage
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Carcinoma, Small Cell / blood
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Carcinoma, Small Cell / drug therapy
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Carcinoma, Small Cell / epidemiology
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Carcinoma, Small Cell / genetics*
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Carcinoma, Small Cell / radiotherapy
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Carcinoma, Small Cell / surgery
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Chemotherapy, Adjuvant
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Child
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Diseases in Twins
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Etoposide / administration & dosage
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Family Health
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Female
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Hormone Replacement Therapy
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Humans
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Hypercalcemia / etiology
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Incidence
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Menopause, Premature
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Ovarian Neoplasms / blood
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Ovarian Neoplasms / drug therapy
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Ovarian Neoplasms / epidemiology
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Ovarian Neoplasms / genetics*
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Ovarian Neoplasms / radiotherapy
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Ovarian Neoplasms / surgery
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Ovariectomy
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Pedigree
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Radiotherapy, Adjuvant
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Remission Induction
Substances
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Bleomycin
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Etoposide
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Cisplatin