Abstract
Chemokines are members of the super family of cytokines necessary for leukocyte recruitment in tissues and lymphoid organs. The interferon-gamma inducible protein-10 (IP-10) chemo-attracts CXCR3-expressing cells, such as activated T lymphocytes and monocytes. We have genetically engineered a strain of Lactococcus lactis to secrete a biologically active murine IP-10 that interacts with human CXCR3, its homolog receptor, and chemo-attracts human CD3+ T lymphocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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CD3 Complex / metabolism*
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Chemotactic Factors / pharmacology*
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Chemotaxis / drug effects
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Humans
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Lactococcus lactis / metabolism*
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Lymphocytes / cytology
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Lymphocytes / drug effects*
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Mice
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Molecular Sequence Data
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Receptors, Cytokine / chemistry
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Receptors, Cytokine / metabolism*
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Sequence Alignment
Substances
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CD3 Complex
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Chemotactic Factors
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IP10-Mig receptor
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Receptors, Cytokine