Efficient synthesis of the indoloazocine framework via intramolecular alkyne carbocyclization

Pavel A Donets; Kristof Van Hecke; Luc Van Meervelt; Erik V Van der Eycken

doi:10.1021/ol901356h

Efficient synthesis of the indoloazocine framework via intramolecular alkyne carbocyclization

Org Lett. 2009 Aug 20;11(16):3618-21. doi: 10.1021/ol901356h.

Authors

Pavel A Donets¹, Kristof Van Hecke, Luc Van Meervelt, Erik V Van der Eycken

Affiliation

¹ Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Katholieke UniVersiteit LeuVen,Celestijnenlaan 200F, B-3001 LeuVen, Belgium.

PMID: 19610606
DOI: 10.1021/ol901356h

Abstract

A microwave-assisted protocol based on an Hg(OTf)(2) catalyzed intramolecular alkyne carbocyclization reaction was developed for selective construction of the indoloazocine core.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry*
Azocines / chemical synthesis*
Azocines / chemistry
Catalysis
Combinatorial Chemistry Techniques
Cyclization
Indoles / chemical synthesis*
Indoles / chemistry
Microwaves
Molecular Structure

Substances

Alkynes
Azocines
Indoles