Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp. GB 4-2

J Antibiot (Tokyo). 2009 Sep;62(9):513-8. doi: 10.1038/ja.2009.64. Epub 2009 Jul 17.

Abstract

Piceamycin, a new macrolactam polyketide antibiotic, was detected by HPLC-diode array screening in extracts of Streptomyces sp. GB 4-2, which was isolated from the mycorrhizosphere of Norway spruce. The structure of piceamycin was determined by mass spectrometry and NMR experiments. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and protein tyrosine phosphatase 1B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcysteine / chemistry
  • Acetylcysteine / metabolism*
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / pharmacology
  • Gram-Positive Bacteria / drug effects
  • Humans
  • Lactams, Macrocyclic / chemistry*
  • Lactams, Macrocyclic / metabolism
  • Lactams, Macrocyclic / pharmacology
  • Microbial Sensitivity Tests
  • Mycorrhizae / metabolism
  • Picea / microbiology
  • Plant Roots / microbiology
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors
  • Recombinant Proteins / antagonists & inhibitors
  • Streptomyces / growth & development
  • Streptomyces / metabolism*

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Lactams, Macrocyclic
  • Recombinant Proteins
  • piceamycin
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Acetylcysteine