Integr-ating IL-1 alpha in antiviral host defenses

Immunity. 2009 Jul 17;31(1):7-9. doi: 10.1016/j.immuni.2009.07.001.

Abstract

Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity.

Publication types

  • Comment

MeSH terms

  • Adenoviridae / immunology*
  • Animals
  • Genetic Therapy
  • Genetic Vectors / immunology*
  • Immunity, Innate
  • Inflammation / immunology
  • Inflammation / virology*
  • Integrin beta3 / immunology*
  • Interleukin-1alpha / immunology*
  • Mice

Substances

  • Integrin beta3
  • Interleukin-1alpha