Mechanical stability of proteins

J Chem Phys. 2009 Jul 14;131(2):024121. doi: 10.1063/1.3170940.

Abstract

A number of experiments and experimentally based simulations showed that beta-proteins are mechanically more stable than alpha-proteins. However, the theory that might explain this evidence is still lacking. In this paper we have developed a simple elastic theory, which allows to estimate critical forces for stretching both kinds of proteins. It has been shown that unfolding of beta-proteins does really require notably higher forces as compared to the stretching of alpha-proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomechanical Phenomena
  • Computer Simulation
  • Elasticity
  • Models, Molecular
  • Protein Folding
  • Protein Stability
  • Proteins / chemistry*
  • Proteins / classification
  • Stress, Mechanical*

Substances

  • Proteins