The purpose of this study is to describe the curriculum development and introduction of problem-based learning pedagogy (PBL) in the undergraduate nursing education at Savonia University of Applied Sciences in Iisalmi unit. The main points to be described are the integration of PBL and e-learning methods and nursing students' learning outcomes in clinical practice. PBL pedagogy develops information literacy skills, critical thinking and evidence-based nursing skills, communication, co-operation and team working skills, problem solving and self-assessment skills. Integration of PBL and e-learning methods in clinical practice has developed nursing competencies, reflection of learning and peer support of nursing students. The most important results are peer support, feedback and a teacher's encouragement when using e-learning methods.