A new bifunctional chelator for copper radiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides

Chem Commun (Camb). 2009 Jun 14:(22):3237-9. doi: 10.1039/b903426a. Epub 2009 Apr 23.

Abstract

A new sarcophagine cage amine ligand with a pendent carboxylate functional group has been synthesised; the ligand has been conjugated to tumour targeting peptides ([Tyr3]-octreotate and [Lys3]-bombesin) and the conjugates radiolabelled with copper-64.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Animals
  • Carboxylic Acids / chemistry*
  • Chelating Agents / chemistry*
  • Copper / chemistry*
  • Cross-Linking Reagents / chemistry*
  • Humans
  • Ligands
  • Peptides / chemistry*
  • Radiopharmaceuticals / chemistry*

Substances

  • Amines
  • Carboxylic Acids
  • Chelating Agents
  • Cross-Linking Reagents
  • Ligands
  • Peptides
  • Radiopharmaceuticals
  • Copper