Cell-induced intracellular controlled release of membrane impermeable cysteine from a mesoporous silica nanoparticle-based drug delivery system

Renato Mortera; Juan Vivero-Escoto; Igor I Slowing; Edoardo Garrone; Barbara Onida; Victor S-Y Lin

doi:10.1039/b900559e

Cell-induced intracellular controlled release of membrane impermeable cysteine from a mesoporous silica nanoparticle-based drug delivery system

Chem Commun (Camb). 2009 Jun 14:(22):3219-21. doi: 10.1039/b900559e. Epub 2009 May 7.

Authors

Renato Mortera¹, Juan Vivero-Escoto, Igor I Slowing, Edoardo Garrone, Barbara Onida, Victor S-Y Lin

Affiliation

¹ Dipartimento di Scienza dei Materiali e Ingegneria Chimica Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino, Italy.

PMID: 19587919
DOI: 10.1039/b900559e

Abstract

A mesoporous silica nanoparticle-based intracellular cysteine delivery system that could be induced and regulated by cell-produced natural antioxidants was synthesized.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antioxidants / metabolism
Cell Membrane Permeability*
Cell Proliferation / drug effects
Cysteine / chemistry
Cysteine / metabolism*
Cysteine / pharmacology
Drug Carriers / chemistry*
HeLa Cells
Humans
Intracellular Space / metabolism*
Metal Nanoparticles / chemistry*
Porosity
Silicon Dioxide / chemistry*

Substances

Antioxidants
Drug Carriers
Silicon Dioxide
Cysteine