Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations

Chem Commun (Camb). 2009 Jul 28:(28):4230-2. doi: 10.1039/b907268c. Epub 2009 Jun 9.

Abstract

Utilizing enzymatic mismatched DNA-specific cleavage and electrocatalytic signaling, a new electrochemical method for the detection of DNA mutations was developed and successfully applied to detect various mutations in the BRCA1 gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pair Mismatch*
  • DNA / chemistry*
  • DNA / genetics
  • Electrochemistry / methods*
  • Genes, BRCA1
  • Humans
  • Mutation*

Substances

  • DNA