Picosecond polarized supercontinuum generation controlled by intermodal four-wave mixing for fluorescence lifetime imaging microscopy

Opt Express. 2008 Nov 10;16(23):18844-9. doi: 10.1364/oe.16.018844.

Abstract

We present the generation of a picosecond polarized supercontinuum in highly birefringent multimodal microstructured fiber. The initial steps of the spectral broadening are dominated by intermodal four-wave mixing controlled by the specific fiber design. Using a low repetition rate ultra-stable solid state laser, a pulse train well-suited for versatile time-domain fluorescence lifetime imaging applications is obtained.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer-Aided Design
  • Equipment Design
  • Equipment Failure Analysis
  • Fiber Optic Technology / instrumentation*
  • Image Enhancement / instrumentation*
  • Microscopy, Fluorescence / instrumentation*
  • Microscopy, Polarization / instrumentation*
  • Refractometry / instrumentation*
  • Reproducibility of Results
  • Sensitivity and Specificity