Promising effect of aromatase inhibitors on recurrent granulosa cell tumors

Int J Gynecol Cancer. 2009 Jul;19(5):830-3. doi: 10.1111/IGC.0b013e3181a261d7.

Abstract

Recurring adult-type granulosa cell tumors of the ovary are usually treated by surgical resection followed by chemotherapy or radiation. However, the results of such treatment are disappointing. We describe 4 patients in whom recurrent ovarian granulosa cell tumors were treated with an aromatase inhibitor, with promising results.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Anastrozole
  • Aromatase Inhibitors / therapeutic use*
  • Female
  • Granulosa Cell Tumor / drug therapy*
  • Granulosa Cell Tumor / pathology
  • Granulosa Cell Tumor / surgery
  • Humans
  • Letrozole
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy*
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery
  • Nitriles / therapeutic use*
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Ovariectomy
  • Prognosis
  • Treatment Outcome
  • Triazoles / therapeutic use*

Substances

  • Aromatase Inhibitors
  • Nitriles
  • Triazoles
  • Anastrozole
  • Letrozole