Abstract
This open-label, randomised, controlled study examined antibody persistence following infant vaccination at 2, 3 and 4 months of age with either an acellular pertussis, diphtheria, tetanus, inactivated poliovirus, Haemophilus influenzae type b (DT(5)aP-IPV-Hib; Pediacel) or a whole-cell pertussis (DTwP//Hib+oral poliomyelitis vaccine [OPV]) combination vaccine, given concomitantly with meningococcal serogroup C conjugate (MCC) vaccine, followed by a Hib booster at approximately 15 months of age. Immune responses were sustained to 3.5-4.5 years of age for all antigens contained in Pediacel. Administration of an acellular pertussis-containing quadrivalent pre-school booster (Td(5)ap-IPV; Repevax), with or without measles, mumps and rubella (M-M-RII) vaccine, induced robust antibody responses indicative of protection, regardless of the vaccine used for the primary series. Reactogenicity of Repevax was acceptable and consistent with previous experience.
Publication types
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Antibodies, Viral / blood*
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Antibodies, Viral / immunology
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Child, Preschool
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
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Diphtheria-Tetanus-Pertussis Vaccine / immunology*
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Haemophilus Vaccines / administration & dosage
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Haemophilus Vaccines / immunology*
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Humans
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Immunization, Secondary*
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Infant
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Measles-Mumps-Rubella Vaccine / administration & dosage
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Measles-Mumps-Rubella Vaccine / immunology
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Meningococcal Vaccines / administration & dosage
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Meningococcal Vaccines / immunology*
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Poliovirus Vaccine, Inactivated / administration & dosage
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Poliovirus Vaccine, Inactivated / immunology*
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Poliovirus Vaccine, Oral / administration & dosage
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Poliovirus Vaccine, Oral / immunology
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United Kingdom
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Vaccines, Combined / administration & dosage
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Vaccines, Combined / immunology
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Vaccines, Conjugate / administration & dosage
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Vaccines, Conjugate / immunology
Substances
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Antibodies, Viral
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Diphtheria-Tetanus-Pertussis Vaccine
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Haemophilus Vaccines
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Measles-Mumps-Rubella Vaccine
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Meningococcal Vaccines
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Poliovirus Vaccine, Inactivated
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Poliovirus Vaccine, Oral
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Vaccines, Combined
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Vaccines, Conjugate
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diphtheria-tetanus-five component acellular pertussis-inactivated poliomyelitis -Haemophilus influenzae type b conjugate vaccine
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serogroup C meningococcal conjugate vaccine