Role of Nod2 in the development of Crohn's disease

Microbes Infect. 2009 Oct;11(12):912-8. doi: 10.1016/j.micinf.2009.06.005. Epub 2009 Jun 30.

Abstract

Crohn's Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Crohn Disease / immunology*
  • Crohn Disease / pathology*
  • Cytokines / immunology
  • Humans
  • Inflammation / pathology*
  • Macrophages / immunology
  • Models, Biological
  • Monocytes / immunology
  • Mutant Proteins / genetics*
  • Mutant Proteins / immunology*
  • Nod2 Signaling Adaptor Protein / genetics*
  • Nod2 Signaling Adaptor Protein / immunology*

Substances

  • Cytokines
  • Mutant Proteins
  • NOD2 protein, human
  • Nod2 Signaling Adaptor Protein