Clostridium difficile strains from community-associated infections

J Clin Microbiol. 2009 Sep;47(9):3004-7. doi: 10.1128/JCM.00964-09. Epub 2009 Jul 1.

Abstract

Clostridium difficile isolates from presumed community-associated infections (n = 92) were characterized by toxinotyping, pulsed-field gel electrophoresis, tcdC and cdtB PCR, and antimicrobial susceptibility. Nine toxinotypes (TOX) and 31 PFGE patterns were identified. TOX 0 (48, 52%), TOX III (18, 20%), and TOX V (9, 10%) were the most common; three isolates were nontoxigenic.

MeSH terms

  • ADP Ribose Transferases / genetics
  • Bacterial Proteins / genetics
  • Bacterial Toxins / analysis
  • Bacterial Typing Techniques
  • Clostridioides difficile / classification*
  • Clostridioides difficile / isolation & purification*
  • Cluster Analysis
  • Community-Acquired Infections / microbiology*
  • DNA Fingerprinting
  • Electrophoresis, Gel, Pulsed-Field
  • Enterocolitis, Pseudomembranous / microbiology*
  • Genotype
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Epidemiology
  • Polymerase Chain Reaction / methods
  • Repressor Proteins / genetics

Substances

  • Bacterial Proteins
  • Bacterial Toxins
  • Repressor Proteins
  • TcdC protein, Clostridium difficile
  • ADP Ribose Transferases
  • actin-specific ADP-ribosyltransferase, Clostridium