Abstract
Background:
In case reports and observational studies, serotonin reuptake-inhibitors (SSRIs) have been linked to an increased risk of bleeding, possibly due to platelet dysfunction as a consequence of serotonin-uptake blockade into platelets.
Objective:
The authors propose that bleeding as a result of SSRI use may also be caused by other mechanisms.
Method:
Here, the authors report on a 32-year-old woman with hemorrhages resulting from severe drug-induced immune thrombocytopenia after 4 weeks of citalopram therapy.
Results:
After withdrawal of citalopram and treatment with platelet concentrates and prednisolone, the patient recovered completely.
Conclusion:
As this case report shows, drug-induced immune thrombocytopenia may present another possible mechanism for bleeding in SSRI-treated patients.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antidepressive Agents, Second-Generation / adverse effects*
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Antidepressive Agents, Second-Generation / therapeutic use
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Autoantibodies / blood
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Autoimmune Diseases / blood
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Autoimmune Diseases / chemically induced*
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Autoimmune Diseases / therapy
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Blood Platelets / immunology
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Citalopram / adverse effects*
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Citalopram / therapeutic use
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Depressive Disorder, Major / blood
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Depressive Disorder, Major / drug therapy*
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Female
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Humans
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Immunosuppressive Agents / therapeutic use
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Platelet Count
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Platelet Transfusion
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Prednisolone / therapeutic use
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Purpura / blood
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Purpura / chemically induced*
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Thrombocytopenia / blood
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Thrombocytopenia / chemically induced*
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Thrombocytopenia / therapy
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Uterine Hemorrhage / blood
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Uterine Hemorrhage / chemically induced*
Substances
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Antidepressive Agents, Second-Generation
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Autoantibodies
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Immunosuppressive Agents
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Citalopram
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Prednisolone