Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Katerina Spyridonidou; Manolis Fousteris; Marazioti Antonia; Athanasia Chatzianastasiou; Andreas Papapetropoulos; Sotiris Nikolaropoulos

doi:10.1016/j.bmcl.2009.06.047

Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4810-3. doi: 10.1016/j.bmcl.2009.06.047. Epub 2009 Jun 14.

Authors

Katerina Spyridonidou¹, Manolis Fousteris, Marazioti Antonia, Athanasia Chatzianastasiou, Andreas Papapetropoulos, Sotiris Nikolaropoulos

Affiliation

¹ Department of Pharmacy, Laboratory of Medicinal Chemistry, School of Health Sciences, University of Patras, 26500 Patras, Greece.

PMID: 19560917
DOI: 10.1016/j.bmcl.2009.06.047

Abstract

The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cells, Cultured
Cyclic GMP / metabolism
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Guanylate Cyclase / antagonists & inhibitors*
Guanylate Cyclase / metabolism
Heterocyclic Compounds, 3-Ring / chemical synthesis
Heterocyclic Compounds, 3-Ring / chemistry
Heterocyclic Compounds, 3-Ring / pharmacology
Indoles / chemical synthesis
Indoles / chemistry*
Indoles / pharmacology
Rats
Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors*
Receptors, Cytoplasmic and Nuclear / metabolism
Soluble Guanylyl Cyclase

Substances

Enzyme Inhibitors
Heterocyclic Compounds, 3-Ring
Indoles
Receptors, Cytoplasmic and Nuclear
Guanylate Cyclase
Soluble Guanylyl Cyclase
Cyclic GMP