Abstract
In this issue of Molecular Cell, Zhang and colleagues (Chen et al., 2009) report their identification of p21 as a positive regulator of Nrf2, which extends p53 prosurvival functions through recruitment of a master stress-response regulator.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism
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Adaptor Proteins, Signal Transducing / physiology*
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Animals
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Antioxidants
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Cyclin-Dependent Kinase Inhibitor p21 / genetics
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Cyclin-Dependent Kinase Inhibitor p21 / metabolism
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Cyclin-Dependent Kinase Inhibitor p21 / physiology*
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / metabolism
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Cytoskeletal Proteins / physiology*
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Kelch-Like ECH-Associated Protein 1
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Mice
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Models, Genetic
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NF-E2-Related Factor 2 / genetics
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NF-E2-Related Factor 2 / metabolism
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NF-E2-Related Factor 2 / physiology*
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Oxidation-Reduction
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Oxidative Stress
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Reactive Oxygen Species / metabolism
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Signal Transduction
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism
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Tumor Suppressor Protein p53 / physiology*
Substances
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Adaptor Proteins, Signal Transducing
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Antioxidants
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Cdkn1a protein, mouse
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Cyclin-Dependent Kinase Inhibitor p21
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Cytoskeletal Proteins
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Keap1 protein, mouse
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Kelch-Like ECH-Associated Protein 1
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NF-E2-Related Factor 2
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Nfe2l2 protein, mouse
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Reactive Oxygen Species
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Tumor Suppressor Protein p53