Abstract
We report the design, synthesis, membrane activity, biophysical characterization, and in vitro antibacterial activities of cationic cyclic D,L-alpha-glycopeptides bearing d-glucosamine (GlcNH(2)), D-galactose (Gal), or D-mannose (Man) glycosyl side chains.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Bacteria / drug effects
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Dose-Response Relationship, Drug
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Drug Design
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Erythrocytes / drug effects
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Glycopeptides / chemical synthesis
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Glycopeptides / chemistry*
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Glycopeptides / pharmacology
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Hemolysis / drug effects
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Humans
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Mice
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Microbial Sensitivity Tests
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NIH 3T3 Cells
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Peptides, Cyclic / chemical synthesis
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / pharmacology
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Stereoisomerism
Substances
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Anti-Bacterial Agents
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Glycopeptides
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Peptides, Cyclic