New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis

Chembiochem. 2009 Jul 20;10(11):1801-5. doi: 10.1002/cbic.200900246.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminobenzoates / chemistry
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Benzoquinones / chemistry*
  • Benzoquinones / pharmacology
  • Biocatalysis
  • Cell Line, Tumor
  • Humans
  • Hydroxybenzoates
  • Lactams, Macrocyclic / chemistry*
  • Lactams, Macrocyclic / pharmacology
  • Mutation
  • Polyketide Synthases / metabolism
  • Streptomyces / enzymology
  • Streptomyces / genetics

Substances

  • Aminobenzoates
  • Antineoplastic Agents
  • Benzoquinones
  • Hydroxybenzoates
  • Lactams, Macrocyclic
  • 3-amino-5-hydroxybenzoic acid
  • Polyketide Synthases
  • geldanamycin