Abstract
Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide, regulates a wide variety of cellular functions, but little is known about its role in neuronal cell migration. Recent studies revealed that PACAP has short-term, cortical layer-specific effects on neuronal cell migration. In this article, we focus on the role of PACAP in controlling the migration of cerebellar granule cells.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Movement / drug effects
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Cell Movement / physiology*
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Cerebellum / cytology*
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Gene Expression / drug effects
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Neurons / drug effects
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Neurons / physiology*
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Neurotransmitter Agents / pharmacology
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Pituitary Adenylate Cyclase-Activating Polypeptide / agonists
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Pituitary Adenylate Cyclase-Activating Polypeptide / antagonists & inhibitors
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Pituitary Adenylate Cyclase-Activating Polypeptide / chemistry
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Pituitary Adenylate Cyclase-Activating Polypeptide / pharmacology
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Pituitary Adenylate Cyclase-Activating Polypeptide / physiology*
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Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / metabolism
Substances
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Neurotransmitter Agents
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Pituitary Adenylate Cyclase-Activating Polypeptide
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Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide