Role of PACAP in controlling granule cell migration

Cerebellum. 2009 Dec;8(4):433-40. doi: 10.1007/s12311-009-0121-9. Epub 2009 Jun 23.

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide, regulates a wide variety of cellular functions, but little is known about its role in neuronal cell migration. Recent studies revealed that PACAP has short-term, cortical layer-specific effects on neuronal cell migration. In this article, we focus on the role of PACAP in controlling the migration of cerebellar granule cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / drug effects
  • Cell Movement / physiology*
  • Cerebellum / cytology*
  • Gene Expression / drug effects
  • Neurons / drug effects
  • Neurons / physiology*
  • Neurotransmitter Agents / pharmacology
  • Pituitary Adenylate Cyclase-Activating Polypeptide / agonists
  • Pituitary Adenylate Cyclase-Activating Polypeptide / antagonists & inhibitors
  • Pituitary Adenylate Cyclase-Activating Polypeptide / chemistry
  • Pituitary Adenylate Cyclase-Activating Polypeptide / pharmacology
  • Pituitary Adenylate Cyclase-Activating Polypeptide / physiology*
  • Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / metabolism

Substances

  • Neurotransmitter Agents
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide