Abstract
Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani, with an IC(50) value of 45 microg/mL, while GPE presented an IC(50) value of 49 microg/mL. Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 microg/mL and 7.0 microg/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 microg/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 microg/mL (D6 clone).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / adverse effects
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Antimalarials / isolation & purification
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Antimalarials / pharmacology*
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Baccharis / chemistry*
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Chlorocebus aethiops
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Leishmania donovani / drug effects
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Microbial Sensitivity Tests
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Parasitic Sensitivity Tests
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Phenols / adverse effects
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Phenols / isolation & purification
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Phenols / pharmacology*
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Plant Extracts / adverse effects
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Leaves
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Plasmodium falciparum / drug effects
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Propolis
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Triterpenes / adverse effects
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
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Trypanocidal Agents / adverse effects
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Trypanocidal Agents / isolation & purification
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Trypanocidal Agents / pharmacology*
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Vero Cells
Substances
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Antimalarials
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Phenols
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Plant Extracts
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Triterpenes
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Trypanocidal Agents
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Propolis