Abstract
The synthesis of esters derived from 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-endo-ol, obtained by LiAlH4 reduction of 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-one, is described. Some of these esters showed an appreciable antiarrhythmic activity in rats, as well as moderate hypotensive and local anesthetic activities in rats and mice, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aconitine / pharmacology
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Anesthesia
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Anesthetics, Local / chemical synthesis
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Anesthetics, Local / pharmacology
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Animals
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Anti-Arrhythmia Agents / chemical synthesis*
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Anti-Arrhythmia Agents / pharmacology
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Arrhythmias, Cardiac / chemically induced
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Arrhythmias, Cardiac / prevention & control
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Blood Pressure / drug effects
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Esters
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Heart Rate / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Mice
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Norbornanes / chemical synthesis*
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Norbornanes / pharmacology
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Rats
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Reaction Time / drug effects
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Spectrophotometry, Infrared
Substances
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Anesthetics, Local
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Anti-Arrhythmia Agents
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Esters
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Norbornanes
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7-(diphenylmethylene)bicyclo(2.2.1)heptan-2-ol
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Aconitine