Esters of 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-endo-ol with antiarrhythmic and other activities

Farmaco. 1991 May;46(5):647-56.

Abstract

The synthesis of esters derived from 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-endo-ol, obtained by LiAlH4 reduction of 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-one, is described. Some of these esters showed an appreciable antiarrhythmic activity in rats, as well as moderate hypotensive and local anesthetic activities in rats and mice, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aconitine / pharmacology
  • Anesthesia
  • Anesthetics, Local / chemical synthesis
  • Anesthetics, Local / pharmacology
  • Animals
  • Anti-Arrhythmia Agents / chemical synthesis*
  • Anti-Arrhythmia Agents / pharmacology
  • Arrhythmias, Cardiac / chemically induced
  • Arrhythmias, Cardiac / prevention & control
  • Blood Pressure / drug effects
  • Esters
  • Heart Rate / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Norbornanes / chemical synthesis*
  • Norbornanes / pharmacology
  • Rats
  • Reaction Time / drug effects
  • Spectrophotometry, Infrared

Substances

  • Anesthetics, Local
  • Anti-Arrhythmia Agents
  • Esters
  • Norbornanes
  • 7-(diphenylmethylene)bicyclo(2.2.1)heptan-2-ol
  • Aconitine