Abstract
Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were elucidated using spectroscopic data analysis. Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Drug Screening Assays, Antitumor
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HL-60 Cells
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Histone Deacetylase Inhibitors*
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification*
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Oleanolic Acid / pharmacology*
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Plant Stems / chemistry
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Taiwan
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Triterpenes / pharmacology*
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Ursolic Acid
Substances
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Antineoplastic Agents, Phytogenic
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Histone Deacetylase Inhibitors
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Triterpenes
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Oleanolic Acid