You don't need a PHD to grow a tumor

Dev Cell. 2009 Jun;16(6):781-2. doi: 10.1016/j.devcel.2009.06.001.

Abstract

Prolyl hydroxylases (PHDs) perceive intracellular oxygen tension and signal hypoxia-inducible factors (HIFs) to induce hypoxia-adaptive processes such as angiogenesis. A paper from Chan and colleagues in the June issue of Cancer Cell demonstrates that PHD2 inactivation in tumor cells accelerates tumor growth via HIF-independent, NF-kappaB-mediated changes in tumor angiogenesis.

MeSH terms

  • Animals
  • Cell Proliferation
  • Hypoxia-Inducible Factor 1 / metabolism
  • Mice
  • NF-kappa B / metabolism
  • Neoplasms / blood supply
  • Neoplasms / enzymology*
  • Neoplasms / pathology*
  • Neovascularization, Pathologic / enzymology
  • Oxygen / metabolism
  • Procollagen-Proline Dioxygenase / metabolism*
  • Signal Transduction

Substances

  • Hypoxia-Inducible Factor 1
  • NF-kappa B
  • Procollagen-Proline Dioxygenase
  • Oxygen