Cleaner continuous photo-oxidation using singlet oxygen in supercritical carbon dioxide

Angew Chem Int Ed Engl. 2009;48(29):5322-5. doi: 10.1002/anie.200901731.

Abstract

High pressure under the spotlight: A new milliliter-scale reactor is developed for using supercritical CO(2) to perform continuous photo-oxidation reactions. Changing from a traditional microliter-scale batch reaction to 8 hours of reaction using the new reactor gives a 3000-fold scale-up of the oxidation of alpha-terpinene (see picture).