Serotonin metabolism parameters in patients with chronic hepatitis and liver cirrhosis

A S Alekseeva; E I Beloborodova; M I Rachkovskiy; E L Naumova; E G Lambrov; L P Philippova

doi:10.1007/s10517-009-0353-1

Serotonin metabolism parameters in patients with chronic hepatitis and liver cirrhosis

Bull Exp Biol Med. 2008 Nov;146(5):577-9. doi: 10.1007/s10517-009-0353-1.

Authors

A S Alekseeva¹, E I Beloborodova, M I Rachkovskiy, E L Naumova, E G Lambrov, L P Philippova

Affiliation

¹ Department of Therapy, Faculty of Upgrading and Postgraduate Training of Physicians, Siberian State Medical University, Tomsk, Russia.

PMID: 19526095
DOI: 10.1007/s10517-009-0353-1

Abstract

We studied disorders in serotonin metabolism in patients with chronic hepatitis and cirrhosis of the liver with and without inflammatory process (cytolysis syndrome) and their impact for the formation of depressive disorders. Blood serotonin content decreased in patients with cirrhosis of the liver with pronounced depressive disorders. Serum serotonin level was elevated in all patients with the cytolysis syndrome.

MeSH terms

Adult
Depressive Disorder / blood
Depressive Disorder / complications*
Depressive Disorder / physiopathology
Female
Hepatitis, Chronic / blood*
Hepatitis, Chronic / complications*
Hepatitis, Chronic / pathology
Humans
Liver Cirrhosis / blood*
Liver Cirrhosis / complications*
Liver Cirrhosis / pathology
Male
Middle Aged
Serotonin / blood*
Young Adult

Substances

Serotonin