Comparison of GnRH antagonist protocol with or without oral contraceptive pill pretreatment and GnRH agonist low-dose long protocol in low responders undergoing IVF/intracytoplasmic sperm injection

Fertil Steril. 2009 Nov;92(5):1758-60. doi: 10.1016/j.fertnstert.2009.05.013. Epub 2009 Jun 12.

Abstract

This prospective randomized study was performed to compare the efficacy of GnRH antagonist multiple-dose protocol (MDP) with or without oral contraceptive pill (OCP) pretreatment and GnRH agonist low-dose long protocol (LP) in 82 patients undergoing IVF/intracytoplasmic sperm injection (ICSI). GnRH antagonist MDP with OCP pretreatment was at least as effective as GnRH agonist low-dose LP in low responders, and can benefit the low responders by reducing the amount of FSH and the number of days of stimulation required for follicular maturation.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Contraceptives, Oral / administration & dosage*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Resistance / drug effects
  • Drug Resistance / physiology
  • Drug Therapy, Combination
  • Female
  • Fertilization in Vitro* / methods
  • Follicle Stimulating Hormone / administration & dosage
  • Gonadotropin-Releasing Hormone / agonists*
  • Gonadotropin-Releasing Hormone / antagonists & inhibitors*
  • Hormone Antagonists / administration & dosage
  • Humans
  • Male
  • Ovulation Induction / methods
  • Pregnancy
  • Sperm Injections, Intracytoplasmic*
  • Tablets
  • Treatment Outcome

Substances

  • Contraceptives, Oral
  • Hormone Antagonists
  • Tablets
  • Gonadotropin-Releasing Hormone
  • Follicle Stimulating Hormone