Abstract
This prospective randomized study was performed to compare the efficacy of GnRH antagonist multiple-dose protocol (MDP) with or without oral contraceptive pill (OCP) pretreatment and GnRH agonist low-dose long protocol (LP) in 82 patients undergoing IVF/intracytoplasmic sperm injection (ICSI). GnRH antagonist MDP with OCP pretreatment was at least as effective as GnRH agonist low-dose LP in low responders, and can benefit the low responders by reducing the amount of FSH and the number of days of stimulation required for follicular maturation.
Publication types
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Contraceptives, Oral / administration & dosage*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Drug Resistance / drug effects
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Drug Resistance / physiology
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Drug Therapy, Combination
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Female
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Fertilization in Vitro* / methods
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Follicle Stimulating Hormone / administration & dosage
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Gonadotropin-Releasing Hormone / agonists*
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Gonadotropin-Releasing Hormone / antagonists & inhibitors*
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Hormone Antagonists / administration & dosage
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Humans
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Male
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Ovulation Induction / methods
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Pregnancy
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Sperm Injections, Intracytoplasmic*
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Tablets
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Treatment Outcome
Substances
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Contraceptives, Oral
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Hormone Antagonists
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Tablets
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Gonadotropin-Releasing Hormone
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Follicle Stimulating Hormone