The influence of class II transactivator and interleukin-6 polymorphisms on the production of antibodies to donor human leucocyte antigen mismatches in renal allograft recipients

Int J Immunogenet. 2009 Aug;36(4):235-9. doi: 10.1111/j.1744-313X.2009.00854.x. Epub 2009 Jun 11.

Abstract

The influence of polymorphisms in the CIITA and IL-6 genes on donor-specific human leucocyte antigen antibody production was investigated in a cohort of renal transplant recipients and their donors. CIITA and IL-6 single nucleotide polymorphisms were found to be associated with donor-specific human leucocyte antigen antibody production post-transplantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Genotype
  • Graft Rejection / genetics
  • Graft Rejection / immunology*
  • Humans
  • Interleukin-6 / genetics*
  • Interleukin-6 / immunology
  • Isoantibodies / biosynthesis*
  • Isoantibodies / blood
  • Kidney Transplantation / immunology*
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / immunology
  • Pilot Projects
  • Polymorphism, Single Nucleotide / genetics
  • Polymorphism, Single Nucleotide / immunology
  • Tissue Donors
  • Trans-Activators / genetics*
  • Trans-Activators / immunology

Substances

  • Interleukin-6
  • Isoantibodies
  • MHC class II transactivator protein
  • Nuclear Proteins
  • Trans-Activators