RNA interference in cancer: targeting the anti-apoptotic protein c-FLIP for drug discovery

Mini Rev Med Chem. 2009 Jun;9(6):741-8. doi: 10.2174/138955709788452748.

Abstract

The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis* / drug effects
  • Apoptosis* / genetics
  • CASP8 and FADD-Like Apoptosis Regulating Protein / genetics*
  • CASP8 and FADD-Like Apoptosis Regulating Protein / metabolism*
  • Drug Discovery*
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • RNA Interference*
  • Signal Transduction

Substances

  • CASP8 and FADD-Like Apoptosis Regulating Protein