In this paper, the curvature changes and fission routes of the lipid domains in a multicomponent vesicle are studied by dissipative particle dynamics. Under different conditions of asymmetric distribution of lipids in two leaflets of lipid bilayer and area-to-volume ratio of the vesicle, we obtained different configurations of the domain in the vesicle: three typical curvature characters of the lipid domain, namely, positive, negative, and invariable curvatures compared to the vesicle are observed. Furthermore, some other morphologies of the domain and two vesicle fission routes (i.e., exocytic and endocytic fissions) are also obtained in our simulations. Particular emphasis is put on the formation of the negative curvature domain and on the behavior of endocytic fission. Based on our simulations, it is indicated that water plays an important role in the invagination and endocytic fission processes of the domain in a vesicle. For endocytic fission, domains of different sizes are evolved according to different routes under the effect of the water. Additionally, we find that both the spontaneous curvature of lipid molecules and area-to-volume ratio can promote or restrain the shape deformation of the lipid domain. Under the competition of these two factors, another possible route of endocytic fission is observed in our simulations, in that only a part of the lipid domain invaginates into the interior of the vesicle to complete the endocytic fission. Our study is helpful for understanding the possible mechanism of the shape transformation of the cellular membrane and the difference of several kinds of routes of vesicle fission.