Abstract
The dermal absorption potential of a nanocrystalline magnesium oxide (MgO) and titanium dioxide (TiO(2)) mixture in dermatomed human skin was assessed in vitro using Bronaugh-type flow-through diffusion cells. Nanocrystalline material was applied to the skin surface at a dose rate of 50 mg/cm(2) as a dry powder, as a water suspension, and as a water/surfactant (sodium lauryl sulfate) suspension, for 8 hours. Dermal absorption of nanocrystalline MgO and TiO(2) through human skin with intact, functional stratum corneum was not detectable under the conditions of this experiment.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Administration, Topical
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Adult
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Diffusion Chambers, Culture
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Humans
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In Vitro Techniques
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Magnesium Oxide / administration & dosage
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Magnesium Oxide / blood
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Magnesium Oxide / chemistry
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Magnesium Oxide / pharmacokinetics*
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Magnesium Oxide / toxicity
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Microscopy, Electron, Transmission
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Models, Biological
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Nanoparticles*
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Skin / drug effects*
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Skin / metabolism
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Skin / ultrastructure
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Skin Absorption*
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Titanium / administration & dosage
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Titanium / blood
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Titanium / chemistry
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Titanium / pharmacokinetics*
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Titanium / toxicity
Substances
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titanium dioxide
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Magnesium Oxide
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Titanium