Investigation of changes in NO content during long-term sensitization in edible snail using EPR-spectroscopy: effects of antibodies to calcium-binding protein S-100
Bull Exp Biol Med. 2008 Dec;146(6):675-9.
doi: 10.1007/s10517-009-0367-8.
[Article in
English,
Russian]
Affiliation
- 1 E. K. Zavoiskii Kazan' Physicotechnical Institute, Russian Academy of Sciences, Novosibirsk, Russia. gainutdinov@mail.knc.ru
Abstract
EPR-spectroscopy experiments (electron paramagnetic resonance) demonstrated a decrease in NO production in the nervous system and heart of edible snail Helix lucorum after formation of long-term sensitization, a neurobiological model of anxiety and depression. The protective effect of antibodies to Ca(2+)-binding protein S-100 in dilution of 10(-12) on the formation of long-term sensitization was accompanied by partial recovery of NO synthesis in the nervous system and heart. These findings indicate that the imbalance in Ca(2+)-binding protein S-100 can lead to inhibition or modulation of some processes during plastic reorganization in the body and especially during pathological processes.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
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Antibodies / immunology
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Antibodies / pharmacology*
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Electron Spin Resonance Spectroscopy
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Helix, Snails / drug effects*
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Helix, Snails / physiology*
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Nitric Oxide / metabolism*
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S100 Proteins / immunology*
Substances
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Antibodies
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S100 Proteins
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Nitric Oxide