Pharmacokinetic study of a carbamazepine nanoemulsion in beagle dogs

Gislaine Kuminek; Jadel M Kratz; Rodrigo Ribeiro; Regina G Kelmann; Bibiana V de Araújo; Helder F Teixeira; Cláudia M O Simões; Letícia S Koester

doi:10.1016/j.ijpharm.2009.05.055

Pharmacokinetic study of a carbamazepine nanoemulsion in beagle dogs

Int J Pharm. 2009 Aug 13;378(1-2):146-8. doi: 10.1016/j.ijpharm.2009.05.055. Epub 2009 Jun 6.

Authors

Gislaine Kuminek¹, Jadel M Kratz, Rodrigo Ribeiro, Regina G Kelmann, Bibiana V de Araújo, Helder F Teixeira, Cláudia M O Simões, Letícia S Koester

Affiliation

¹ Programa de Pós-Graduação em Farmácia, Centro de Ciências da Saúde, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, 88.040-900 Florianópolis, SC, Brazil.

PMID: 19501150
DOI: 10.1016/j.ijpharm.2009.05.055

Abstract

This work describes the pharmacokinetics of a novel carbamazepine nanoemulsion. The plasma concentration profiles were determined in beagle dogs after i.v. bolus administration of a 5 mg/kg carbamazepine nanoemulsion and compared to the corresponding carbamazepine/hydroxypropyl-beta-cyclodextrin complex solution. Both formulations showed similar pharmacokinetic profiles and could represent valuable formulations in case of emergencies, when a rapid action in the central nervous system is desirable.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

2-Hydroxypropyl-beta-cyclodextrin
Animals
Anticonvulsants / administration & dosage
Anticonvulsants / pharmacokinetics*
Carbamazepine / administration & dosage
Carbamazepine / pharmacokinetics*
Cross-Over Studies
Dogs
Emulsions
Excipients / chemistry*
Female
Injections, Intravenous
Nanoparticles
Random Allocation
beta-Cyclodextrins / chemistry*

Substances

Anticonvulsants
Emulsions
Excipients
beta-Cyclodextrins
2-Hydroxypropyl-beta-cyclodextrin
Carbamazepine