This study analyzes the significant impacts of typhoons and earthquakes on land cover change and hydrological response. The occurrence of landslides following typhoons and earthquakes is a major indicator of natural disturbance. The hydrological response of the Chenyulan watershed to land use change was assessed from 1996 to 2005. Land use changes revealed by seven remote images corresponded to typhoons and a catastrophic earthquake in central Taiwan. Hydrological response is discussed as the change in quantities and statistical distributions of hydrological components. The land cover change results indicate that the proportion of landslide relative to total area increased to 6.1% after the Chi-Chi earthquake, representing the largest increase during the study period. The study watershed is dominated by forest land cover. Comparisons of hydrological components reveal that the disturbance significantly affects base flow and direct runoff. The hydrological modeling results demonstrate that the change in forest area correlates with the variation of base flow and direct runoff. Base flow and direct runoff are sensitive to land use in discussions of distinction. The proposed approach quantifies the effect of typhoons and earthquakes on land cover changes.